Meta Description:
Learn everything about Adefovir Dipivoxil – an antiviral medicine for chronic hepatitis B. Discover its uses, mechanism, dosage, side effects, precautions, and FAQs.
Introduction
Adefovir Dipivoxil is an antiviral medication used in the treatment of chronic hepatitis B virus (HBV) infection. It belongs to a group of medicines called nucleotide reverse transcriptase inhibitors (NtRTIs).
It helps lower the amount of hepatitis B virus in the body, improves liver function, and reduces the risk of liver damage. However, it is not a cure for hepatitis B and must be used under strict medical supervision.
What is Adefovir Dipivoxil Used For?
Adefovir Dipivoxil is mainly prescribed for:
Chronic Hepatitis B infection
Patients who do not respond to other antiviral treatments like Lamivudine
Reducing the risk of liver cirrhosis and liver cancer caused by long-term HBV infection
How Does Adefovir Dipivoxil Work?
Adefovir Dipivoxil is converted inside the body to its active form, Adefovir.
It works by blocking reverse transcriptase, an enzyme the hepatitis B virus needs to multiply.
By preventing viral replication, it reduces the viral load and slows down liver damage.
In short, it stops the virus from spreading but does not completely remove it from the body.
Dosage & Usage
Adults (Chronic Hepatitis B): 10 mg once daily, taken by mouth with or without food.
Children (12–17 years): 10 mg once daily (if prescribed).
Duration: Long-term treatment may be required.
Missed dose: Take as soon as you remember, but skip if it’s almost time for the next dose. Do not double dose.
Always take Adefovir exactly as prescribed by your doctor.
Side Effects
Common Side Effects:
Weakness, headache
Stomach pain, diarrhea, nausea
Flatulence (gas)
Serious Side Effects (seek medical help immediately):
Kidney problems (increased creatinine, kidney failure in rare cases)
Lactic acidosis (symptoms: deep/rapid breathing, fatigue, muscle pain)
Severe liver problems (jaundice, dark urine, abdominal swelling)
Precautions
Kidney disease patients should be closely monitored, as Adefovir may worsen kidney function.
Regular liver and kidney function tests are required during treatment.
Do not stop treatment suddenly – this may cause hepatitis flare-ups.
Pregnant or breastfeeding women should use only if prescribed by a doctor.
Not recommended for HIV patients unless combined with other HIV medications.
Frequently Asked Questions (FAQ)
1. Is Adefovir Dipivoxil a cure for hepatitis B?
Answer: No, it is not a cure. It controls the infection, reduces liver damage, and lowers viral load, but hepatitis B may come back if treatment is stopped.
2. How long should I take Adefovir Dipivoxil?
Answer: It may need to be taken for months or years, depending on liver condition and doctor’s advice. Regular monitoring is necessary.
3. Can Adefovir Dipivoxil cause kidney problems?
Answer: Yes, long-term use may affect kidney function. Doctors usually monitor creatinine levels during therapy.
4. Can I drink alcohol while taking Adefovir Dipivoxil?
Answer: Alcohol can worsen liver damage. It is strongly advised to avoid alcohol during hepatitis B treatment.
5. What happens if I stop taking Adefovir suddenly?
Answer: Stopping suddenly can cause severe hepatitis flare-ups, leading to rapid liver damage. Always consult your doctor before discontinuing.
Conclusion
Adefovir Dipivoxil is an effective antiviral medication for chronic hepatitis B. It helps reduce viral load, slows down liver damage, and lowers the risk of serious complications. However, it must be used under strict medical supervision with regular monitoring of liver and kidney function.
