Metronidazole: Complete Guide to Uses, Dosage, Side Effects & Precautions

 

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Metronidazole is an antibiotic and antiprotozoal medicine used for bacterial and protozoal infections. Learn about its uses, dosage, side effects, precautions, quick reference chart, and FAQs in this complete guide.

What is Metronidazole?

Metronidazole is an antibiotic and antiprotozoal drug from the nitroimidazole group. It is effective against anaerobic bacteria and protozoa by damaging their DNA, leading to cell death.
Doctors prescribe it for infections in the stomach, intestines, reproductive system, gums, skin, and blood.

Medical Uses of Metronidazole

Bacterial Infections

Bacterial vaginosis

Dental infections (gum abscess, periodontal disease)

Intra-abdominal infections and abscesses

Skin and soft tissue infections

Protozoal Infections

Amoebiasis (Entamoeba histolytica)

Giardiasis (Giardia lamblia)

Trichomoniasis (Trichomonas vaginalis)

Other Uses

In combination with other drugs for H. pylori (stomach ulcers)

As surgical prophylaxis to prevent infection

Topical cream/gel for rosacea

How Does Metronidazole Work?

Metronidazole enters harmful microorganisms and blocks DNA synthesis. This prevents bacteria and protozoa from multiplying, ultimately killing them.

Dosage Guidelines

Dosage depends on infection type. Always follow a doctor’s advice.

Adults: 400–500 mg orally every 8–12 hours

Children: Weight-based dosage prescribed by doctor

Topical: Apply thin layer on affected skin

Injection: Hospital use for severe cases

Side Effects of Metronidazole

Common Side Effects

Nausea, vomiting, diarrhea

Loss of appetite

Metallic taste in mouth

Headache, dizziness

Serious Side Effects

Numbness, tingling, seizures

Severe allergic reaction (rash, breathing difficulty)

Liver problems (yellow skin, dark urine, abdominal pain)

Precautions & Warnings

Avoid alcohol during treatment and for 48 hours after last dose.

Inform doctor if you have liver/kidney problems, epilepsy, or are pregnant.

Can interact with warfarin, lithium, phenytoin, and cimetidine.

Quick Reference Chart

Category Details

Drug Class Antibiotic & Antiprotozoal
Main Action Disrupts microbial DNA
Common Uses Bacterial vaginosis, dental infections, amoebiasis, giardiasis, trichomoniasis, H. pylori, rosacea
Dosage (Adults) 400–500 mg orally every 8–12 hrs
Dosage (Children) Based on weight
Topical Use Gel/cream applied thinly
Injection For severe infections in hospitals
Common Side Effects Nausea, diarrhea, metallic taste
Serious Side Effects Seizures, allergy, liver problems
Precautions No alcohol, inform doctor if pregnant or with liver/kidney issues
Availability Prescription only

Frequently Asked Questions (FAQ)

Can I take Metronidazole during pregnancy?

Sometimes, yes. Only if your doctor prescribes it.

Can I drink milk or eat dairy while taking Metronidazole?

Yes, dairy is safe. Only alcohol is restricted.

How long does Metronidazole take to work?

Usually 2–3 days to see improvement. But always finish the full course.

Can Metronidazole be combined with other antibiotics?

Yes, often used with amoxicillin or clarithromycin for H. pylori infections.

Is it available without prescription?

No, it is prescription-only medicine.

Infographic Content (For Design)

Title: Metronidazole: Key Facts

Sections: Uses, Dosage, Side Effects (Common + Serious), Precautions, Quick Reminder

Colors: Green & Blue (medical theme)

Icons: Pills, bacteria, stomach, warning signs, doctor advice

Conclusion

Metronidazole is a highly effective medicine against bacterial and protozoal infections. However, it should never be taken without a doctor’s advice. Always complete the full course, avoid alcohol, and follow medical supervision to ensure safe treatment.

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